ChloroquineV1, France, Analysis, bibRecord, 000016

Hydroxychloroquine for prevention of recurrent miscarriage: study protocol for a multicentre randomised placebo-controlled trial BBQ study

Identifieur interne : 000016 ( France/Analysis ); précédent : 000015; suivant : 000017

Hydroxychloroquine for prevention of recurrent miscarriage: study protocol for a multicentre randomised placebo-controlled trial BBQ study

Auteurs : Elisabeth Pasquier [France] ; Luc De Saint-Martin [France] ; Gisèle Marhic [France] ; Céline Chauleur [France] ; Caroline Bohec [France] ; Florence Bretelle [France] ; Véronique Lejeune-Saada [France] ; Jacob Hannigsberg [France] ; Geneviève Plu-Bureau [France] ; Virginie Cogulet [France] ; Philippe Merviel [France] ; Dominique Mottier [France]

Source :

BMJ Open [ 2044-6055 ] ; 2019-03-20.

RBID : Hal:hal-02082511

Abstract

Recurrent miscarriage (RM), defined by three or more consecutive losses during the first trimester of pregnancy, affects 1%–2% of fertile couples. Standard investigations fail to reveal any apparent cause in ~50% of couples. However, on the basis of animal models and clinical studies, several hypotheses have been put forward concerning underlying mechanisms of RM: altered ovarian reserve, progesterone defect, thrombotic and/or endothelial dysfunction and immunological disturbances. Nonetheless, no study has yet reached conclusive beneficial clinical evidence for a potential treatment in unexplained RM. Hydroxychloroquine (HCQ) is a molecule with extensive safety data during pregnancy. The pharmacological properties of HCQ (eg, antithrombotic, vascular protective, immunomodulatory, improved glucose tolerance, lipidlowering and anti-infectious) could be effective against some mechanisms of unexplained RM. Furthermore, eventhough clinical benefit of HCQ is suggested in prevention of thrombotic and late obstetric events in antiphospholipid (APL) syndrome, there are no data suggesting the benefit of HCQ in RM in the presence of APL antibodies.

Url:

https://hal.univ-brest.fr/hal-02082511

DOI: 10.1136/bmjopen-2018-025649

Affiliations:

Links toward previous steps (curation, corpus...)

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Links to Exploration step

Hal:hal-02082511

Le document en format XML

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<idno type="DOI">10.1136/bmjopen-2018-025649</idno>
<series><title level="j">BMJ Open</title>
<idno type="ISSN">2044-6055</idno>
<imprint><date type="datePub">2019-03-20</date>
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<front><div type="abstract" xml:lang="en">              <p>Recurrent miscarriage (RM), defined by three or more consecutive losses during the first trimester of pregnancy, affects 1%–2% of fertile couples. Standard investigations fail to reveal any apparent cause in ~50% of couples. However, on the basis of animal models and clinical studies, several hypotheses have been put forward concerning underlying mechanisms of RM: altered ovarian reserve, progesterone defect, thrombotic and/or endothelial dysfunction and immunological disturbances. Nonetheless, no study has yet reached conclusive beneficial clinical evidence for a potential treatment in unexplained RM. Hydroxychloroquine (HCQ) is a molecule with extensive safety data during pregnancy. The pharmacological properties of HCQ (eg, antithrombotic, vascular protective, immunomodulatory, improved glucose tolerance, lipidlowering and anti-infectious) could be effective against some mechanisms of unexplained RM. Furthermore, eventhough clinical benefit of HCQ is suggested in prevention of thrombotic and late obstetric events in antiphospholipid (APL) syndrome, there are no data suggesting the benefit of HCQ in RM in the presence of APL antibodies.</p>
            </div>
</front>
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<name sortKey="Merviel, Philippe" sort="Merviel, Philippe" uniqKey="Merviel P" first="Philippe" last="Merviel">Philippe Merviel</name>
<name sortKey="Mottier, Dominique" sort="Mottier, Dominique" uniqKey="Mottier D" first="Dominique" last="Mottier">Dominique Mottier</name>
<name sortKey="Plu Bureau, Genevieve" sort="Plu Bureau, Genevieve" uniqKey="Plu Bureau G" first="Geneviève" last="Plu-Bureau">Geneviève Plu-Bureau</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000016 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000016 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Hal:hal-02082511
   |texte=   Hydroxychloroquine for prevention of recurrent miscarriage: study protocol for a multicentre randomised placebo-controlled trial BBQ study
}}

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Chloroquine

Hydroxychloroquine for prevention of recurrent miscarriage: study protocol for a multicentre randomised placebo-controlled trial BBQ study

Hydroxychloroquine for prevention of recurrent miscarriage: study protocol for a multicentre randomised placebo-controlled trial BBQ study

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Abstract

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